论文部分内容阅读
目的 探讨钙通道阻滞剂（ＣＣＥＢ）对肝缺血一再灌注损伤（ＨＩＲＩ）防治作用的机制。方法制备家兔ＨＩＲＩ模型，动态观察维拉帕米（ＶＰ）和地尔硫卓（ＤＴ）对肝组织及血中黄嘌呤氧化酶（ＸＯ）、超氧化物歧化酶（ＳＯＤ）活性及脂质过氧化物（ＬＰＯ）浓度的影响。结果 ＶＰ组和ＤＴ组ＯＸ活性及ＭＤＡ含量分别显著低于对照组（均Ｐ＜０．０１），而ＳＯＤ活性与对照组比较均无显著性差异（均 Ｐ＞ ０．０５）。结论 ＣＣＥＢ抗 ＨＩＲＩ的机制与其降低 ＸＯ活性、抑制脂质过氧化反应密切相关。
Objective To investigate the mechanism of calcium channel blocker (CCEB) on the prevention and treatment of hepatic ischemia-reperfusion injury (HIRI). Methods The HIRI model of rabbits was prepared and the effects of verapamil (VP) and diltiazem (DT) on the activity of xanthine oxidase (XO), superoxide dismutase (SOD) and lipid peroxides (LPO) concentration. Results OX activity and MDA content in VP group and DT group were significantly lower than those in control group (all P <0.01), while there was no significant difference in SOD activity between control group and VP group (all P> 0.05). Conclusion The mechanism of anti-HIRI of CCEB is closely related to the reduction of XO activity and inhibition of lipid peroxidation.