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近年研究表明,细胞内钙参与多个促成动脉粥样硬化(AS)的细胞过程。钙拮抗剂有抗AS作用,有AS斑块的人主动脉及实验性AS动物的主动脉的总钙含量增高,家兔实验性AS的主动脉平滑肌细胞膜对钙的通透性增加近5倍。然而,这些结果多基于尸检组织
Recent studies have shown that intracellular calcium is involved in multiple cellular processes that contribute to atherosclerosis (AS). Calcium antagonists have an anti-AS effect. The total calcium content of the aorta of AS plaques and the aorta of experimental AS animals is increased. The permeability of the aortic smooth muscle cell membrane in rabbits experimental AS is increased by nearly 5 times . However, these results are mostly based on autopsy tissue