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早产儿视网膜病变(ROP)是在早产儿出生时未发育成熟的视网膜血管系统处于相对高氧的环境,进而导致血管停止发育和异常增生的疾病.脂联素(APN)是由脂肪细胞分泌的一种内源性生物活性蛋白,具有调节糖和脂质代谢、抑制动脉粥样硬化和保护心血管系统等作用,近年来研究发现APN还有抑制新生血管形成作用,可能参与ROP的发生及发展.其机制可能通过调节血清肿瘤坏死因子α(TNF-α)、胰岛素样生长因子1(IGF-1)和血管内皮生长因子(VEGF)水平阻止ROP的发生及发展.同时APN的表达也受成纤维细胞生长因子21(FGF21)和长链多不饱和脂肪酸(ω-3 LCPUFAs)的影响.了解APN在ROP中的作用的相关研究现状,可为进一步研究ROP发病机制以及预防治疗提供新的思路.“,”Retinopathy of prematurity ( ROP) is a disease which the retinal vascular system is not mature at birth,leading to cessation of development and abnormal proliferation of blood vessels, in a relatively high oxygen environment. Adiponectin ( APN ) is an endogenous bioactive protein secreted by adipocytes. It has functions of regulating Glucose and lipid metabolism,inhibiting atherosclerosis and protecting the cardiovascular system. APN can inhibit angiogenesis which may be involved in the occurrence and development of ROP in recent research. APN may be regulating the serum level of tumor necrosis factorα(TNF-α),insulin-like growth factor 1 (IGF-1),and vascular endothelial growth factor ( VEGF) A to prevent the development of ROP. The expression of APN is also affected by fibroblast growth factor 21 (FGF-21) and long-chain polyunsaturated fatty acids (ω-3 LCPUFAs) at the same time. Understanding the role of APN in ROP can provide new ideas for further study of the pathogenesis and prevention and treatment of ROP.