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目的通过分析601例产前诊断胎儿疾病而终止妊娠的病历,了解胎儿严重疾病的特点,探讨孕中期血清筛查联合超声筛查预防出生缺陷的相关分析。方法选取嘉兴市妇幼保健院2012年10月~2014年9月在我院经过产前诊断会诊诊断胎儿严重疾病而终止妊娠病历,分析胎儿超声诊断及染色体诊断情况。结果经过我院产前诊断胎儿严重疾病共计601例,超声异常551例(91.68%),染色体异常50例(8.32%)、前5位分别是心血管系统109例(占18.1%),神经系统104例(占16.8%),颜面畸形81例(占13.5%),泌尿系统畸形62例(10.3%),染色体异常(8.3%);其中产前筛查高风险人数78人(12.98%),低风险人数229(38.9%),未做筛查人数294例(48.92%)。结论孕中期血清筛查联合超声筛查可有效降低胎儿出生缺陷,但需要联合运用。
Objective To analyze the history of prenatal diagnosis of fetal diseases in 601 cases of pregnancy termination of pregnancy to understand the characteristics of severe fetal disease to explore the second trimester serum screening combined with ultrasound screening to prevent birth defects related analysis. Methods Jiaxing Maternal and Child Health Hospital from October 2012 to September 2014 in our hospital through prenatal diagnosis consultation diagnosis of fetal serious illness and termination of pregnancy medical record, analysis of fetal ultrasound diagnosis and chromosome diagnosis. Results A total of 601 cases of fetal serious diseases were diagnosed prenatally in our hospital. There were 551 cases (91.68%) with abnormal ultrasound and 50 cases (8.32%) with abnormal chromosomal abnormalities. The top five were 109 cases of cardiovascular system (18.1%), nervous system 104 cases (16.8%), 81 cases (13.5%) of facial deformities, 62 cases (10.3%) of urinary system malformations and 8.3% of chromosomal abnormalities. Among them, 78 were high risk persons (12.98% 229 (38.9%) were low risk and 294 (48.92%) were not screened. Conclusion The second trimester serum screening combined with ultrasound screening can effectively reduce fetal birth defects, but need to be combined.