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肺动脉高压患者停用NO后常常有症状反弹现象,反弹表现为肺动脉(PA)压升高,心肺功能不稳定,有些患者预期治疗结束后仍需继续应用NO,使人们对NO的疗效产生疑问。复发原因部分与体内原有的cGMP瞬时耗竭有关。5-型磷酸二酯酶抑制剂西地那非,有可能通过提高体内cGMP水平预防这种现象发生。为此Namachivayam P等人进行了一项相关研究,研究西地那非对撤除NO治疗后症状反弹的预防作用(反弹是指肺
Patients with pulmonary hypertension often have symptoms of NO after deactivation phenomenon, the rebound showed elevated pulmonary artery (PA), cardiorespiratory instability, and some patients still need to continue to use NO after the end of treatment, so that people have doubts about the efficacy of NO. Reasons for the recurrence in part with the body of the original cGMP transient depletion related. A type 5 phosphodiesterase inhibitor, sildenafil, may prevent this from happening by increasing cGMP levels in the body. To this end, Namachivayam P, who conducted a related study of sildenafil on the prevention of symptoms after removal of NO prophylaxis (rebound refers to the lung