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目的检测孕妇血绒毛膜促性腺激素(β-HCG)和血胱抑素C(Cys C)水平,探讨对妊娠期高血压临床价值。方法采用化学发光法及全自动生化分析仪对100例妊娠期高血压疾病孕妇及100例正常孕妇的血清进行血β-HCG及血Cys C的检测。结果重度子痫前期组孕妇血β-HCG和血Cys C分别为(51 076±34 037)m IU/m L和(1.62±0.43)mg/L,轻度子痫前期组孕妇血β-HCG和血Cys C分别为(46 689±25 925)m IU/m L和(1.26±0.30)mg/L,与正常孕妇组(36 672±26 295)m IU/m L和(0.80±0.18)mg/L比较,均明显升高,差异有统计学意义(P<0.01);重度子痫前期组血β-HCG与轻度子痫前期组血β-HCG相比,差异无统计学意义(P>0.05),而重度子痫前期组血Cys C与轻度子痫前期组血Cys C相比,明显增高,差异有统计学意义(P<0.01)。结论血β-HCG的检测有助于妊娠期高血压疾病的诊断,同时,血Cys C对妊娠期高血压疾病所造成的肾功能损害更具有较好的诊断价值,并可作为判断其病情轻重的指标,联合检测血β-HCG及血Cys C对了解其病情进程更具指导的意义。
Objective To detect the levels of serum chorionic gonadotropin (β-HCG) and cystatin C (Cys C) in pregnant women, and to explore the clinical value of gestational hypertension. Methods The chemiluminescence and automatic biochemical analyzer were used to detect the serum levels of β-HCG and Cys C in 100 pregnant women with gestational hypertension and 100 normal pregnant women. Results The serum levels of β-HCG and Cys C in pregnant women with severe preeclampsia were (51 076 ± 34 037) m IU / m L and (1.62 ± 0.43) mg / And blood Cys C were (46 689 ± 25 925) m IU / m L and (1.26 ± 0.30) mg / L respectively, compared with 36 672 ± 26 295 m IU / m L and (0.80 ± 0.18) mg / L, the difference was statistically significant (P <0.01). There was no significant difference in serum β-HCG between the severe preeclampsia group and the mild preeclampsia group (P <0.01) P> 0.05). However, the level of Cys C in severe preeclampsia group was significantly higher than that in mild preeclampsia group (P <0.01). Conclusion The detection of β-HCG in blood contributes to the diagnosis of hypertensive disorders in pregnancy, meanwhile, the blood Cys C has a better diagnostic value for renal dysfunction caused by hypertensive disorder complicating pregnancy, and can be used as a basis for judging the severity of the disease Of the indicators, combined detection of blood β-HCG and blood Cys C to understand the progress of the disease more instructive significance.