论文部分内容阅读
目的 : 为研究尖锐湿疣患者的细胞免疫状态 ,并为免疫治疗提供依据。方法 : 采用间接免疫荧光法和ELISA法分别对 36例尖锐湿疣 (CA)患者及 2 0例正常人外周血T淋巴细胞亚群、血清白细胞介素 - 2 (IL 2 )水平进行了检测。结果 : CA患者与正常人比较 ,其外周血中CD4+ 细胞百分比及CD4+ /CD8+ 细胞比值降低 (P <0 .0 5 ) ,CD8+ 细胞百分比升高 (P <0 .0 5 ) ,血清IL 2水平降低 (P <0 .0 5 )。结论 :CA患者存在细胞免疫缺陷 ,此可能是CA发生与复发的重要原因之一 ,也为免疫疗法治疗CA提供了实验依据
Objective: To study the cellular immune status of patients with condyloma acuminatum and provide basis for immunotherapy. Methods: T lymphocyte subgroups and serum interleukin - 2 (IL - 2) levels in peripheral blood of 36 condyloma acuminatum (CA) patients and 20 normal individuals were detected by indirect immunofluorescence and ELISA. Results: The percentage of CD4 + cells and the ratio of CD4 + / CD8 + cells in peripheral blood of CA patients were significantly decreased (P <0.05), the percentage of CD8 + cells was increased (P <0.05), the level of IL-2 Decreased (P <0.05). CONCLUSIONS: Cellular immune deficiency exists in CA patients, which may be one of the important reasons for the occurrence and recurrence of CA. It also provides an experimental basis for immunotherapy to treat CA