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目的 :观察肿瘤患者血浆 P-选择素 (P- sel)、层粘连蛋白 (L N)和一氧化氮 (NO)的水平 ,并探讨其临床意义。方法 :用 EL ISA法检测 16 9例不同肿瘤患者血浆中 P- sel和 L N含量 ,比色法检测 NO的含量。结果 :除鼻咽癌组 L N与正常人组间差异无显著性外 ,其余各肿瘤组血浆 P- sel、L N和 NO含量均明显高于正常对照组 (P<0 .0 5或 P<0 .0 1) ,且 P- sel和 L N的升高与 NO呈正相关 (P<0 .0 0 1)。结论 :提示肿瘤患者体内有大量的血小板和内皮细胞活化或遭到破坏 ,细胞外基质也遭到破坏 ,这些变化与 NO的增高可能有一定的关系
Objective: To observe the levels of plasma P-selectin, laminin and nitric oxide in patients with cancer and to explore its clinical significance. Methods: The levels of P-sel and L-N in plasma of 169 patients with different tumors were detected by EL-ISA. The content of NO was detected by colorimetric assay. Results: The plasma levels of P-sel, LN and NO in all the tumor groups were significantly higher than those in the normal control group (P <0.05 or P <0 .0 1), and there was a positive correlation between the increase of P-sel and LN and NO (P <0.01). Conclusion: It suggests that a large number of platelet and endothelial cells in tumor patients are activated or destroyed, and the extracellular matrix is also destroyed. These changes may be related to the increase of NO