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目的：探讨交锁髓内钉和微创经皮锁定钢板（ LISS）内固定治疗闭合性胫腓骨多段骨折的临床疗效。方法2010年12月至2014年10月共收治闭合性胫腓骨多段骨折24例，均予手术治疗，根据手术内固定方法分成两组，髓内钉固定组16例，LISS 钢板固定组8例，比较两组手术时间、手术切口长度、术中出血量、并发症发生率、骨折平均愈合时间及术后 Johner-wruhs 评分等。结果髓内钉固定组手术切口长度、并发症发生率、骨折平均愈合时间均低于LISS 钢板固定组（P ﹤0.05），两组手术时间、术中出血量、术后 Johner-wruhs 评分比较差异未见统计学意义（P ﹥0.05）。结论交锁髓内钉和锁定钢板（LISS）内固定均是治疗闭合性胫骨多段粉碎性骨折的有效方法，术后带锁髓内钉并发症更少，骨折愈合率更高。“,”Objective To investigate the effect of the interlocking intramedullary nail or minimally invasive percutaneous loc-king plate internal fixation(LISS)on closed tibiofibula multiple fractures. Methods From December 2010 to October 2014,24 cases were divided into two groups,according to the operation internal fixation method,16 cases in intramedullary nail fixation group and 8 cases in LISS group;the operation time,incision length,intraoperative blood loss,complications,average healing time of fracture,and postoperative Johner-wruhs score of the two groups were compared. Results The incision length,complica-tion rates,fracture healing time of intramedullary nail fixation group were lower than those of LISS group(P ﹤ 0. 05),there were no significant differences in operation time,intraoperative blood loss,postoperative Johner-wruhs score of the two groups(P ﹥0. 05). Conclusion Interlocking intramedullary nails or locking plate(LISS)internal fixation are effective on closed tibiofibula multiple fractures,and the method using interlocking intramedullary nails has less postoperative complications and higher fracture healing rate.