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安定是治疗破伤风的重要药物。文献报告,成人破伤风时安定血浓度为500ng/ml,即可收到控制抽搐之效,但尚无治疗小儿破伤风该药有效血浓度的报告.本文对住进新德里某医院破伤风病房的3例6～12岁年长儿和3例7～10天新生儿破伤风的安定及其代谢物N去甲安定和甲羟基安定的血浓度作了测定。按抽搐严重度不同,安定的最大用量在年长儿为7.5～15mg/kg/天,新生儿为48～50mg/kg/天。当病情
Diazepam is an important drug for the treatment of tetanus. Reported in the literature, adult tetanus stability blood concentration of 500ng / ml, you can receive the effect of control of convulsions, but no effective treatment of pediatric tetanus drug effective blood concentration report.This article admitted to a hospital in New Delhi tetanus ward The plasma levels of diazepam and its metabolites, n-desmethylstaine and diazepam, were determined in 3 elderly children aged 6 to 12 and in 3 newborns aged 7 to 10 days. According to seizure severity, the maximum amount of stability in older children 7.5 ~ 15mg / kg / day, newborn 48 ~ 50mg / kg / day. When the condition