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目的 :探讨肝硬化 (LC)患者血清一氧化氮 (NO)、一氧化氮合酶 (NOS)浓度变化与肝功能分级及LC并发症间的关系。方法 :分别采用硝酸还原酶法和重叠比色法 ,检测 5 2例LC患者及 30例正常人血清NO和NOS浓度 ,并按患者的肝功能分级、是否伴 无并发症进行比较分析。结果 :LC患者血清NO水平和NOS浓度平均为 12 7.6 7μmol L和 4.2 5U ml,均非常明显地高于正常组 (P <0 .0 0 1) ;肝功能Child -Pugh分级显示 :血清NO水平和NOS浓度在C级显著地高于B级 (P <0 .0 5 )和A级 (P <0 .0 1) ;LC并发食管胃底静脉曲张破裂出血、自发性腹膜炎、肝病性低氧血症患者中血清NO水平和NOS浓度 ,均高于无并发症的LC患者 (P <0 .0 5 )。结论 :本文提示LC患者肝组织中NO和NOS合成增加 ,并与病情严重程度及患者有 无并发症密切相关
Objective: To investigate the relationship between serum concentration of nitric oxide (NO) and nitric oxide synthase (NOS) in patients with liver cirrhosis (LC) and the classification of liver function and LC complications. Methods: Nitric acid reductase method and overlap colorimetric method were used to detect serum NO and NOS concentrations in 52 cases of LC patients and 30 cases of normal controls. The patients’ liver function grading and complication were compared. Results: The serum levels of NO and NOS in LC patients were 12 7.6 7 μmol L and 4.2 5 U ml, both of which were significantly higher than those in the normal group (P <0.01). The liver function Child-Pugh classification showed that serum NO level And NOS concentrations were significantly higher at C level than those at B level (P <0.05) and A level (P <0.01); LC complicated esophageal and gastric variceal bleeding, spontaneous peritonitis, hepatopathic hypoxia Serum NO levels and NOS concentrations were higher in patients with LC than those without LC (P <0.05). Conclusion: This paper suggests that the synthesis of NO and NOS in liver tissue of patients with LC increased, and with the severity of the disease and patients with or without complications are closely related