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目的 探索SDF1 3’A、CCR2 64I、-2 5 18MCP 1基因多态性与系统性红斑狼疮(SLE)自身抗体、临床表现、实验室指标和活动性的相关性。方法 按临床表型和基因型对 12 1例SLE病人分组 ,探索SDF1 3’A、CCR2 64I、-2 5 18MCP 1基因多态性与自身抗体、临床表现、实验室指标和活动性。结果 SDF1 3’A、-2 5 18MCP 1、CCR2 64I基因多态性与SLE自身抗体的产生均无关。而有关节炎病人中 -2 5 18MCP 1G/A基因型频率高于无关节炎病人 (Pc =0 .0 18,OR =3 .0 8,95 %为 1.2 7～ 7.5 7)。三种趋化因子基因多态性与血清中IgG、IgA、IgM、C3 、C4、ESR水平和SLE DAI间均未见相关性 (P >0 .0 5 )。结论 -2 5 18MCP 1基因多态性与SLE病人的关节炎发生有关。
Objective To explore the relationship between SDF1 3’A, CCR2 64I, -2 5 18MCP 1 gene polymorphisms and autoantibodies, clinical manifestations, laboratory parameters and activities of systemic lupus erythematosus (SLE). Methods According to clinical phenotype and genotype, 121 cases of SLE patients were divided into groups to explore the relationship between SDF1 3’A, CCR2 64I, -2 5 18MCP 1 gene polymorphisms and autoantibodies, clinical manifestations, laboratory indexes and activities. Results SDF1 3’A, -25 18MCP 1, CCR2 64I gene polymorphism and SLE autoantibodies have nothing to do. However, the frequency of -2 5 18 MCP 1 G / A genotype in arthritis patients was higher than that in non-arthritis patients (Pc = 0.018, OR = 3.08, 95% = 1.2 7 ~ 7.5 7). There was no correlation between the three chemokine gene polymorphisms and serum IgG, IgA, IgM, C3, C4, ESR levels and SLE DAI (P> 0.05). Conclusion -2 5 18MCP 1 gene polymorphism and SLE patients with arthritis.