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目的:分析食管鳞癌(ESCC)细胞系的染色体异常,为将来寻找食管癌相关基因提供线索。方法:采用比较基因组杂交法(CGH)分析3种ESCC细胞系的染色体DNA拷贝数改变情况。结果:9q(3/3)、3q(2/3)、5q(2/3)、5p(2/3)、8q(2/3)、12p(2/3)和20q(2/3)为常见的染色体增加区。4q(2/3)和6q(2/3)是常见的染色体丢失区。结论:这些常见的染色体异常有助于寻找和定位食管癌相关基因。
Objective: To analyze the chromosomal abnormalities in esophageal squamous cell carcinoma (ESCC) cell lines and provide clues for the future search of esophageal cancer related genes. Methods: Chromosome DNA copy number changes of three ESCC cell lines were analyzed by comparative genomic hybridization (CGH). Results: 9q (3/3), 3q (2/3), 5q (2/3), 5p (2/3), 8q (2/3), 12p (2/3) and 20q (2/3) Common for the chromosomes to increase the area. 4q (2/3) and 6q (2/3) are common regions of chromosomal loss. Conclusion: These common chromosomal abnormalities help to find and locate esophageal cancer related genes.