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【目的】探讨乙型肝炎病毒 (HBV)母婴垂直传播的规律 ,为预防和阻断HBV的母婴传播提供依据。【方法】对 6 8例HBsAg阳性孕产妇以荧光定量PCR方法检测其静脉血、脐血、乳汁HBVDNA含量并分析其相关性。【结果】孕妇血与脐血HBVDNA的含量相关系数为 0 34 46 (P =0 0 0 8) ,孕妇血与乳汁HBVDNA的含量的相关系数为 0 144 9(P =0 2 6 1)。【结论】孕妇血HBVDNA水平与脐血HBVDNA水平呈正相关 ,降低孕妇血HBVDNA水平 ,有利于控制HBV宫内感染 ;对HBsAg阳性产妇应检测乳汁HBVDNA ,以便指导母乳喂养。
【Objective】 To investigate the law of vertical transmission of hepatitis B virus (HBV) between mother and infant, and provide basis for preventing and blocking the transmission of HBV from mother to infant. 【Methods】 HBsAg in 68 cases of HBsAg positive pregnant women with venous blood, umbilical cord blood and milk samples were detected by fluorescence quantitative PCR and the correlation was analyzed. [Results] The correlation coefficient of HBVDNA between pregnant women and umbilical blood was 0 34 46 (P = 0 0 0 8). The correlation coefficient of HBVDNA between blood and milk of pregnant women was 0 144 9 (P = 0 2 6 1). 【Conclusion】 The level of serum HBVDNA in pregnant women is positively correlated with the level of HBVDNA in umbilical cord blood, which can reduce the level of HBV DNA in pregnant women and control the intrauterine HBV infection. HBsAg in breast milk should be detected in HBsAg-positive pregnant women in order to guide breastfeeding.