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用ELISA 法定量检测生育、不育男性血清、精浆抗SPIM 自身抗体(SPIM-Ab)。结果表明:不育组和妻子流产组患者血清、精浆SPIM-Ab 含量均显著高于生育组(P<0.01),两组血清、精浆的SPIM-Ab 阳性率与生育组之间有显著性差异(P<0.01);精浆SPIM-Ab 含量高于5.0U/ml 时,精于密度、精子活率及精浆SPIM 活性均明显降低;SPIM-Ab 与血清、精浆抗精子抗体(AsAb)无明显关系。提示:SPIM-Ab 水平增加可能抑制SPIM 活性、与SPIM一起参与局部免疫反应,并减少精子密度和活率。
Quantitative detection by ELISA of fertile, sterile male serum, seminal plasma anti-SPIM autoantibodies (SPIM-Ab). The results showed that the content of SPIM-Ab in serum and seminal plasma of infertile group and wife miscarriage group were significantly higher than that of fertility group (P <0.01). The positive rate of SPIM-Ab in serum and seminal plasma between two groups was significantly higher than that of fertility group (P <0.01). When the content of SPIM-Ab in seminal plasma was higher than 5.0 U / ml, the density, the sperm motility and the activity of seminal plasma SPIM were significantly decreased. SPIM-Ab and serum and seminal plasma anti-sperm antibody AsAb) no significant relationship. Tip: Increased SPIM-Ab levels may inhibit SPIM activity, participate in local immune responses with SPIM, and reduce sperm density and viability.