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从有机胂的角度出发,结合丹皮酚的抗炎、活血和抗肿瘤等特性,合成了一系列的有关丹皮酚和有机胂的衍生物,均为创新化合物;采用正交实验和方差分析对合成化合物的条件进行了探讨,同时对丹皮酚的提取条件进行了优化研究;以创新化合物对人肝癌细胞株HepG2细胞的抗肿瘤活性进行了筛选,获得效果较佳的化合物和最佳的试验浓度,通过对HepG2细胞生长抑制实验、诱导HepG2细胞凋亡分析及机制等的探讨,探索了一类结构简单、较低浓度下可以诱导体外及体内肿瘤细胞凋亡,而对正常细胞影响较小的新型有机胂药物.
From the perspective of organic arsine, a series of derivatives of paeonol and organic arsine were synthesized based on the anti-inflammatory, blood-activating and anti-tumor properties of paeonol, all of which were innovative compounds. The orthogonal test and analysis of variance The conditions for the synthesis of compounds were discussed, and the conditions for the extraction of paeonol were optimized. The anti-tumor activity of the compounds on HepG2 cells was screened by innovative compounds and the best compounds Test concentration, HepG2 cell growth inhibition experiments induced HepG2 cell apoptosis analysis and mechanism of exploration, to explore a class of simple structure, lower concentration can induce in vitro and in vivo tumor cell apoptosis, but the impact on normal cells Small new organic arsine drugs.