论文部分内容阅读
[目的]观察益气活血方联合化疗治疗晚期结直肠癌疗效。[方法]使用随机平行对照方法,将42例住院患者按就诊顺序编号简单随机分为两组。对照组21例草酸铂125mg/m2 iv gtt d1,CF 100mg/m2 iv gtt d1、2,5-FU500 mg/m2 iv d1、2,5-FU 2g连续72h泵入;恩丹西酮8mg iv d1-3hual化疗。治疗组21例益气活血方(紫河车7g,鸡血藤、黄精、生黄芪各25g,熟地15g,当归20g,党参20g,龙眼肉10g,焦白术12g,淮山药30g,水红花子20g,阿胶10g,三七粉3g,茯苓10g),1剂/d,水煎200m L;化疗治疗同对照组。连续治疗15d为1疗程。观测临床症状、肿瘤病灶、不良反应。连续治疗2疗程,判定疗效。[结果]治疗组完全缓解4例,部分缓解4例,好转8例,进展5例,总有效率76.19%;对照组完全缓解2例,部分缓解4例,好转5例,进展10例,总有效率52.38%;治疗组疗效优于对照组(P<0.05);不良反应治疗组优于对照组(P<0.05)。[结论]益气活血方联合化疗治疗晚期结直肠癌,疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of Yiqi Huoxue prescription combined with chemotherapy on advanced colorectal cancer. [Methods] Using randomized parallel control method, 42 inpatients were randomly divided into two groups according to the order of their visits. The control group 21 cases of oxaliplatin 125mg / m2 iv gtt d1, CF 100mg / m2 iv gtt d1,2,5-FU500 mg / m2 iv d1,2,5-FU 2g continuous 72h pump; ondansetron 8mg iv d1 -3hual chemotherapy. Treatment group, 21 cases of Yiqi Huoxue prescription (Placenta car 7g, Millettia, Polygonatum, raw Astragalus each 25g, Rehmannia 15g, angelica 20g, Codonopsis 20g, longan meat 10g, coke Atractylodes 12g, yam yam 30g, 20g, Ejiao 10g, notoginseng powder 3g, Poria 10g), 1 / d, decoction 200m L; chemotherapy with the control group. Continuous treatment 15d for a course of treatment. Observation of clinical symptoms, tumor lesions, adverse reactions. Continuous treatment of 2 courses to determine the efficacy. [Results] In the treatment group, 4 cases were completely relieved, 4 cases partially relieved, 8 cases improved, 5 cases improved and the total effective rate was 76.19%. In the control group, 2 cases were completely relieved, 4 cases partially relieved, 5 cases improved, and 10 cases progressed. The effective rate was 52.38%. The curative effect of the treatment group was better than that of the control group (P <0.05). The adverse reaction treatment group was better than the control group (P <0.05). [Conclusion] Yiqi Huoxue decoction combined with chemotherapy for advanced colorectal cancer has satisfactory curative effect and no serious adverse reactions, which deserves promotion.