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Ｐ53基因突变、缺乏或失活是多种肿瘤发生的原因[1]。在肺癌中Ｐ53基因蛋白表达阳性率较高,常大于50%[2]。煤工尘肺合并肺癌的Ｐ53基因蛋白表达报道较少,我们以此来探讨煤工尘肺合并肺癌Ｐ53基因蛋白表达与普通肺癌对照组阳性表达、预后有何差异。1 材料与方法11 材料来源
P53 gene mutation, lack of or inactivation is the cause of a variety of tumors [1]. In lung cancer P53 gene protein positive rate is high, often more than 50% [2]. There are few reports of P53 gene expression in coal worker’s pneumoconiosis with lung cancer, so we can explore the difference between the expression of P53 gene in coal worker’s pneumoconiosis and lung cancer positive group and the control group. 1 Materials and methods 11 Source of material