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目的:探讨尼莫地平治疗高血压脑梗死的临床疗效。方法:收治高血压并发脑梗死患者124例,随机分成对照组和观察组,每组62例,对照组采用20%甘露醇、肠溶阿斯匹林50mg,1次/日进行治疗,同时控制血压和血糖。观察组在对照组的基础上加尼莫地平30～60mg,3次/日,两组均治疗14天。结果:观察组基本治愈23例(37.1%),显著进步24例(38.7%),进步23例(37.1%),无变化2例(3.2%),恶化0例,死亡0例,总有效率为96.8%。对照组基本治愈12例(19.4%),显著进步15例(24.2%),进步23例(37.1%),无变化8例(12.9%),恶化4例(6.5%),死亡0例,总有效率为80.6%。观察组神经功能缺损评分与对照组比较差异有显著性(P<0.05);两组与本组治疗前比较亦差异有显著性(P<0.05)。结论:尼莫地平治疗高血压合并脑梗死疗效显著。
Objective: To investigate the clinical efficacy of nimodipine in the treatment of hypertensive cerebral infarction. Methods: A total of 124 patients with hypertension complicated by cerebral infarction were randomly divided into control group and observation group, with 62 cases in each group. The control group was treated with 20% mannitol and 50 mg enteric-coated aspirin once a day for control Blood pressure and blood sugar. On the basis of the control group, the observation group was treated with nimodipine 30 ~ 60mg, 3 times / day for 14 days. Results: The observation group basically cured in 23 cases (37.1%), significantly improved in 24 cases (38.7%), advanced in 23 cases (37.1%), unchanged in 2 cases (3.2%), exacerbated in 0 cases, 96.8%. In control group, 12 cases (19.4%) were cured, 15 cases (24.2%) were significantly improved, 23 cases (37.1%) were improved, 8 cases (12.9%) did not change, 4 cases (6.5% The effective rate is 80.6%. The score of neurological deficit in the observation group was significantly different from that of the control group (P <0.05). There was also a significant difference between the two groups before treatment (P <0.05). Conclusion: Nimodipine is effective in treating hypertension complicated with cerebral infarction.