新型抗焦虑药

• 作 者: Rubinstein G Norman TR 彭师奇
• 出 处: 国外医药.合成药.生化药.制剂分册
• 发表日期: 1986年03期
• 关键词: 抗焦虑药 利眠宁 安定类药物 药物动力学 超剂量 丁螺环酮 相互作用 二氮 去甲 安慰剂

尽管已有多种类型的药物用于治疗焦虑状态,但安定类药物仍常常是首选药。主要由于它们的有效性,在超剂量时仍然安全,以及与其它常用药物相对来说不易发生相互作用等优点,这类药物仍被认为是极优良的抗焦虑药。从二十年前利眠宁首次应用以来,安定类药物的数目已经大为增加。它们之中有不少可被代谢或经化学转变成去甲安定。而另外一些则是去甲安定的代谢产物。即使在这类药物之间存在明确的药物动力学差异,但要确立它们之间的临床差别却不容易。

Although many types of medications have been used to treat anxiety states, diazepam drugs are often the preferred drug. Mainly because of their effectiveness, safety at overdose, and their relative ease of interaction with other commonly used drugs, these drugs are still considered to be excellent anti-anxiety drugs. The number of diazepam has greatly increased since the initial use of Sheridanning two decades ago. Many of them can be metabolized or chemically converted to norfiban. Others are methotrexate metabolites. Even if there are clear pharmacokinetic differences between these drugs, it is not easy to establish the clinical differences between them.