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Timpl和Hahn等于1979年首先报告用放射免疫法测定血清中游离的Ⅲ型前胶原肽(P-Ⅲ-P).近年来,P-Ⅲ-P已被公认是纤维化活性的良好指标,对各种肝病肝纤维化的诊断很有价值.对15名正常男性成人的测定值为9.9±2.6ng/ml,与各家报告相似.作者以15ng/ml(平均值+2?)以上定为异常高值.测定结果:急性肝炎的极期多数病例P-Ⅲ-P增高,但随着炎症的消退呈急骤下降倾向,因此对测定值的评价应考虑采血的时期.52例慢性肝炎的含量范围为5.0～86.7ng/ml,平均值为19.31±17.27mg/ml.其中25例作肝活检,慢性肝组P-Ⅲ-P为30.96±29.97ng/ml,而慢肝非活动组为11.35±6.29ng/ml.但病理组织学上纤维化的程度(胶原的量)与P-Ⅲ-P
Timpl and Hahn were the first to report the determination of free type III procollagen peptide (P-III-P) in serum by radioimmunoassay in 1979. In recent years, P-III-P has been recognized as a good indicator of fibrotic activity, The diagnosis of various liver diseases is of great value, with a reported value of 9.9 ± 2.6 ng / ml for 15 normal male adults, which is similar to reports from each of the individuals.With 15 ng / ml (mean +2?) And above, Abnormal high value.Results: The most acute cases of P-Ⅲ P increased, but declined sharply with the propensity to decline, so the determination of the value of the evaluation should take into account the period of blood collection .52 cases of chronic hepatitis In the range of 5.0 ~ 86.7ng / ml, with an average of 19.31 ± 17.27mg / ml.Among these 25 cases, liver biopsy showed P-Ⅲ-P was 30.96 ± 29.97ng / ml in chronic liver and 11.35% ± 6.29ng / ml.But the degree of histopathological fibrosis (the amount of collagen) and P-Ⅲ-P