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目的 :研究胃癌患者围术期血小板膜糖蛋白 CD4 1 、CD6 2 P含量的变化和分布位置的变化 ,为进一步研究肿瘤细胞的生长、转移与血小板膜糖蛋白 CD4 1 、CD6 2 P形态、结构变化的关系奠定基础 ,为围术期防凝抗凝提供客观依据。方法 :应用免疫电镜技术检测 9例胃癌患者围术期 CD4 1 、CD6 2 P表达的变化 ,同时选择年龄相当的正常人 5例作对照。结果 :与正常人相比 ,胃癌患者 CD4 1 、CD6 2 P表达增多 ,手术使血小板活化更为加剧 ,同时观察到 CD4 1 、CD6 2 P明显的形态、结构的改变。结论 :胃癌患者血小板膜糖蛋白 CD4 1 、CD6 2 P表达和释放增加 ,处于激活状态 ;手术促使血小板活化进一步加强。
Objective: To study the changes of peripherical platelet membrane glycoproteins CD4 1 and CD62P levels and their distribution in order to further study the growth and metastasis of tumor cells and platelet membrane glycoproteins CD4 1 and CD6 2 P morphology and structure. The basis for the changes in the relationship, to provide an objective basis for perioperative anticoagulant anticoagulation. Methods : Immunoelectron microscopy was used to detect the changes of CD4 1 and CD6 2 P expression in 9 patients with gastric cancer during perioperative period. At the same time, 5 normal controls with age were selected as controls. RESULTS: The expression of CD4 1 and CD62P in gastric cancer patients increased compared with normal controls. The platelet activation was further aggravated by surgery. At the same time, the obvious morphological and structural changes of CD4 1 and CD6 2 P were observed. Conclusion :The expression and release of platelet membrane glycoproteins CD4 1 and CD6 2 P are increased in gastric cancer patients. The platelet activation is further enhanced by surgery.