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目的探析2型糖尿病肾病(DN)患者不同分期血清脂联素水平及影响因素。方法 87例糖尿病肾病患者作为观察组,根据24 h尿微量白蛋白水平分为正常组(37例)、微量组(30例)及大量组(20例),以同期接受健康体检者85例作为对照组。比较各组甘油三酯(TG)、肌酐(Cr)、空腹血糖(FPG)、糖化血红蛋白(Hb A1c)、餐后2 h血糖(2 h PG)及尿白蛋白定量(UAER)、血清脂联素(ADPN)等指标。结果各组患者体质量指数(BMI)的两两比较差异无统计学意义(P>0.05),FPG、2 h PG两两比较差异均有统计学意义(P<0.05)。2型糖尿病肾病患者不同分期ADPN水平与年龄、病程、Hb A1c、UAER、FPG、2 h PG等指标均有明显相关性。结论糖尿病肾病不同分期患者血清ADPN水平存在较大差异,以病程、糖代谢控制状态为主要影响因素,早治疗、严格控制代谢指标可延缓病情、改善预后。
Objective To investigate the serum levels of adiponectin in patients with type 2 diabetic nephropathy (DN) and its influencing factors. Methods 87 patients with diabetic nephropathy were divided into normal group (37 cases), micro-group (30 cases) and large-scale group (20 cases) according to the level of 24-hour urine microalbumin. Eighty- Control group. The levels of triglyceride (TG), creatinine (Cr), fasting blood glucose (FPG), Hb A1c, 2 h postprandial blood glucose (2 h PG) and urinary albumin quantitation (UAER) Prime (ADPN) and other indicators. Results There was no significant difference in body mass index (BMI) between the two groups (P> 0.05). The difference of FPG and 2 h PG was statistically significant (P <0.05). ADPN levels in patients with type 2 diabetic nephropathy at different stages were significantly correlated with age, duration of disease, Hb A1c, UAER, FPG, 2 h PG and other indicators. Conclusions The levels of ADPN in patients with diabetic nephropathy at different stages are quite different. The course of disease and the status of glycometabolism control are the main influencing factors. Early treatment and strict control of metabolic indices can delay the progression of the disease and improve the prognosis.