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目的：探讨早期肠内营养支持对重症急性胰腺炎（SAP）患者的影响。方法选取2011年1月—2014年1月厦门大学附属福州市第二医院收治的 SAP 患者200例，按随机分组法将其分为观察组与对照组，各100例。观察组患者予以空肠内营养，对照组患者予以全胃肠外营养。观察两组患者临床疗效、治疗前后肠道功能和APACHEⅡ评分、治疗前和治疗1周免疫功能指标（IgG、IgA、IgM）及感染情况。结果两组患者临床疗效比较，差异无统计学意义（P ﹥0.05）；治疗前两组患者肠道功能和 APACHEⅡ评分比较，差异无统计学意义（P ﹥0.05）；治疗后观察组患者肠道功能和 APACHEⅡ评分低于对照组，差异有统计学意义（ P ﹤0.05）；治疗前两组患者血清IgG、IgA、IgM 水平比较，差异无统计学意义（P ﹥0.05）；治疗1周观察组患者血清 IgG、IgA、IgM 水平高于对照组，差异有统计学意义（P ﹤0.05）；观察组患者感染发生率低于对照组，差异有统计学意义（P ﹤0.05）。结论早期肠内营养支持可减少 SAP 患者感染，改善患者肠道功能，增强患者免疫功能。“,”Objective To investigate the impact of early enteral nutritional support on patients with severe acute pan-creatitis(SAP). Methods A total of 200 patients with SAP were selected in the Second Affiliated Hospital of Xiamen Univer-sity from January 2011 to January 2014,according to the random grouping method,they were divided into observation group and control group,100 cases in each group. Observation group were given enteral nutrition,control group were given total parenteral nutrition. Clinical effect,before and after treatment intestinal function and APACHE Ⅱ score,before treatment and 1 week after treatment immune function(IgG,IgA,IgM)and infection situation between the two groups were compared. Results Clinical effect showed no significant differences between the two groups(P ﹥ 0. 05);before treatment,intestinal function and APACHEⅡ score showed no significant differences between the two groups( P ﹥ 0. 05),after treatment,intestinal function and A-PACHE Ⅱ score of observation group were lower than those of control group(P ﹤ 0. 05);before treatment,serum IgG,IgA, IgM level showed no significant differences between the two groups(P ﹥ 0. 05),1 week after treatment,serum IgG,IgA,IgM level of observation group were higher than those of control group(P ﹤ 0. 05);infection rate of observation group was lower than that of control group(P ﹤ 0. 05). Conclusion Early enteral nutritional support can reduce infection in patients with SAP,im-prove intestinal function and enhance immune function.