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目的探讨子宫外子宫内膜间质肉瘤(ESS)的临床病理特点、组织发生及鉴别诊断。方法回顾2例ESS的临床及病理资料,并辅以免疫组化分析。结果 2例患者均以盆腔包块和腹痛入院,其中1例伴有子宫内膜异位症。组织学显示瘤细胞由浸润性、弥漫性的单一圆形或梭形细胞组成,类似增生期子宫内膜间质细胞,螺旋小动脉可见。其中1例瘤细胞异型、坏死明显,为低分化ESS。免疫组化:瘤细胞CD10、vimentin、ER和PR均(+)。结论子宫外ESS的发生与异位的子宫内膜相关,CD10、vimentin和PR是标记ESS较好的一组抗体。
Objective To investigate the clinicopathological features, histogenesis and differential diagnosis of extrauterine endometrial stromal sarcoma (ESS). Methods The clinical and pathological data of 2 ESS cases were retrospectively analyzed and analyzed by immunohistochemistry. Results Both patients were admitted with pelvic mass and abdominal pain. One patient had endometriosis. Histologically, tumor cells are composed of infiltrative, diffuse, single round or spindle cells, similar to proliferative endometrial stromal cells, visible in the helical arterioles. One case of abnormal tumor cells, necrosis obvious, poorly differentiated ESS. Immunohistochemistry: The tumor cells CD10, vimentin, ER and PR were (+). Conclusions The occurrence of extrauterine ESS is related to the ectopic endometrium. CD10, vimentin and PR are a good group of antibodies labeled with ESS.