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目的 :研究心力衰竭 (HF)患者血浆纤溶酶原激活物抑制物 1(PAI 1)和血管紧张素Ⅱ (AngⅡ )的变化 ,并探讨两者之间的关系。方法 :分别采用酶联免疫吸附法和放射免疫法测定 6 0例HF患者 (HF组 )及 2 0例健康人 (正常对照组 )血浆PAI 1抗原、AngⅡ水平。结果 :HF组血浆PAI 1抗原、AngⅡ水平比正常对照组明显增高 ,并且与心功能状态有关。血浆PAI 1抗原含量与AngⅡ水平呈正相关 (r =0 .994 ,P <0 .0 1)。结论 :AngⅡ是PAI 1合成与释放的重要调节者之一 ,二者相互影响可加速心功能的恶化。
Objective: To investigate the changes of plasma plasminogen activator inhibitor 1 (PAI 1) and angiotensin Ⅱ (Ang Ⅱ) in patients with heart failure (HF) and to explore the relationship between the two. Methods: Plasma PAI 1 antigen and Ang Ⅱ levels in 60 HF patients and 20 normal controls (normal control group) were determined by enzyme-linked immunosorbent assay and radioimmunoassay respectively. Results: Plasma PAI 1 antigen and Ang Ⅱ levels in HF group were significantly higher than those in normal control group, and were associated with cardiac function. Plasma PAI 1 antigen levels and Ang Ⅱ levels were positively correlated (r = 0.994, P <0.01). CONCLUSION: Ang II is one of the important regulators of PAI 1 synthesis and release, and the interaction between them can accelerate the deterioration of cardiac function.