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本文作者给10名早孕妇女采用内含15-甲基PGF_(2α)甲基酯(u-36,384)的阴道栓治疗,同时连续测定周围血浆中15-甲基PGF_(2α),黄体酮和雌二醇水平,并测定子宫安静和活动时压力,希望进一步揭示PG的作用机制。 10名孕妇的年龄为23.1±1.9,孕次1.9±0.4,产次0～4±0.2,孕龄10.9±0.5周。取血尿标本检查,重复测定重要体征并用微型气囊连续记录子宫内压4小时。在给阴道栓后,0、0.5、1、2、4和8小时连续采肘静脉血测定PG和激素。从开始
In this study, 10 pregnant women were treated with vaginal suppository containing 15-methyl PGF 2α methyl ester (u-36,384), while continuous determination of 15-methyl PGF 2α, progesterone and estradiol Diol level, and determination of uterine sedation and activity pressure, hoping to further reveal the mechanism of action of PG. The age of 10 pregnant women was 23.1 ± 1.9, the pregnancy time was 1.9 ± 0.4, the parity was 0 ~ 4 ± 0.2, and the gestational age was 10.9 ± 0.5 weeks. Hematuria specimens were taken for examination, vital signs were repeatedly measured and intrauterine pressure was continuously recorded for 4 hours using a mini-balloon. After the vaginal suppository, 0, 0.5, 1, 2, 4 and 8 hours continuous extraction of venous blood samples were measured PG and hormone. From the beginning