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探讨血浆内皮素（ＥＴ）在急性脑血管病（ＡＣＶＤ）发病过程中的变化规律及其损伤神经系统的机制和对ＡＣＶＤ病因学、临床诊断、治疗和判断预后的临床应用价值。用放射免疫法测定了７４例ＡＣＶＤ患者血浆ＥＴ浓度，并以３０例年龄相近的正常人作对照分析。结果：ＡＣＶＤ组ＥＴ浓度显著高于对照组（ｔ＝３１．４７，Ｐ＜０．００１）；脑出血、脑梗塞和脑出血加脑梗塞各组间年龄与性别无显著差别（Ｐ＞０．０５）。表明ＡＣＶＤ的发生与发展与ＥＴ有关。
To investigate the changes of plasma endothelin (ET) in the pathogenesis of acute cerebrovascular disease (ACVD) and its mechanism of damaging the nervous system and its clinical value in the etiology, clinical diagnosis, treatment and prognosis of ACVD. The plasma ET levels in 74 patients with ACVD were measured by radioimmunoassay and compared with 30 healthy individuals of similar age. Results: The ET concentration in ACVD group was significantly higher than that in control group (t = 31.47, P <0.001). There was no significant difference in the age and sex among the groups of cerebral hemorrhage, cerebral infarction and cerebral hemorrhage plus cerebral infarction (P> 0. 05). Show that the occurrence and development of ACVD and ET.