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目的:探讨骨桥蛋白(OPN)在子宫内膜异位症(EMS)患者血清中表达的临床意义。方法:选择2009年2月～2012年2月在该院接受治疗的40例EMS患者作为研究组,并选择40例卵巢良性肿瘤患者作为对照组。采用ELISA法对两组患者手术前、后血清中的骨桥蛋白含量进行检测。结果:研究组患者手术前血清中OPN平均水平为(30.64±12.3)ng/ml,手术后血清中OPN平均水平为(15.54±9.3)ng/ml;对照组患者手术前血清中OPN平均水平为(14.68±10.2)ng/ml,手术后血清中OPN平均水平为(14.08±9.8)ng/ml。研究组手术前血清OPN水平高于手术后以及对照组手术前,差异有统计学意义(P<0.01),对照组术前术后比较差异无统计学意义(P>0.05)。Ⅲ～Ⅳ期EMS患者血清中OPN平均水平高于Ⅰ～Ⅱ期患者,差异有统计学意义(P<0.01)。结论:OPN在EMS患者血清中表达水平比较高,可以辅助EMS患者的临床诊断。随着病情的加重,OPN表达水平逐渐增高,这有助于对患者的病情分期,便于对EMS的临床治疗。
Objective: To investigate the clinical significance of osteopontin (OPN) expression in sera of patients with endometriosis (EMS). Methods: Forty EMS patients treated in our hospital from February 2009 to February 2012 were selected as the study group, and 40 patients with benign ovarian tumors were selected as the control group. The levels of osteopontin in serum of the two groups before and after surgery were detected by ELISA. Results: The average level of OPN in preoperative serum was (30.64 ± 12.3) ng / ml and the average level of OPN in postoperative serum was (15.54 ± 9.3) ng / ml in the study group. The average level of OPN in the preoperative serum was (14.68 ± 10.2) ng / ml respectively. The average level of OPN in serum after operation was (14.08 ± 9.8) ng / ml. The level of serum OPN in the study group before surgery was significantly higher than that before surgery and in the control group before surgery (P <0.01), but there was no significant difference in the control group before and after surgery (P> 0.05). The level of serum OPN in stage Ⅲ ~ Ⅳ EMS patients was higher than that in stage Ⅰ ~ Ⅱ patients, the difference was statistically significant (P <0.01). Conclusion: OPN is highly expressed in the serum of patients with EMS, which can assist the clinical diagnosis of EMS patients. As the disease aggravates, the expression level of OPN gradually increases, which helps to staging the patient’s condition and facilitates the clinical treatment of EMS.