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目的 探讨细胞周期蛋白E(cyclinE)和p2 7kip1在膀胱移行细胞癌中的表达及临床意义。 方法 采用免疫组化SP法观察 69例膀胱癌石蜡标本中cyclinE和 p2 7kip1的表达情况 ,结合临床资料进行分析。 结果 膀胱癌组织中cyclinE和 p2 7kip1阳性表达率分别为 42 %和 51 %。cy clinE阳性表达率在复发肿瘤中及随病理分级升高而升高 (P <0 .0 5) ,但与临床分期无关 (P >0 .0 5) ;p2 7kip1阳性表达率随病理分级、临床分期升高及在复发肿瘤中下降 (P <0 .0 1 )。cyclinE与 p2 7kip1二者的阳性表达有显著相关性 (P <0 .0 1 )。 结论 cyclinE和p2 7kip1表达可能是判断膀胱癌生物学行为的重要指标
Objective To investigate the expression and clinical significance of cyclin E and p27kip1 in bladder transitional cell carcinoma. Methods The expression of cyclinE and p27kip1 in 69 cases of bladder cancer paraffin specimens was observed by immunohistochemical SP method and analyzed with clinical data. Results The positive rates of cyclinE and p27kip1 in bladder cancer were 42% and 51% respectively. The positive rate of cy-clinE in recurrent tumors and increased with pathological grade (P <0.05), but had no correlation with clinical stage (P> 0.05). The positive rate of p27phiip1 was positively correlated with pathological grade, Clinical stage increased and decreased in recurrent tumors (P <0.01). There was a significant correlation between cyclinE and p27kip1 expression (P <0.01). Conclusions The expressions of cyclinE and p27kip1 may be important indexes in judging the biological behavior of bladder cancer