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甘露醇系渗透性利尿药,在水中的溶解度为1:6,故20%甘露醇注射液为过饱和溶液,放置期间往往有结晶析出。美国药典记载:使用前若有结晶析出,可以温热之,待结晶溶解后方可应用。本品一经形成结晶,即使在室温也不会自溶,尤其冬季甚至在滴注过程中也可形成结晶。由于输液中有细微结晶存在,难以鉴别是否有霉菌与异物,影响危重病人的抢救。为解决甘露醇的结晶问题,我们根据甘露醇与
Mannitol-based osmotic diuretics, the solubility in water is 1: 6, so 20% mannitol injection is supersaturated solution, often during the crystallization. United States Pharmacopoeia records: If there is crystallization before use, you can warm it until the crystals dissolved before use. Once the product is crystallized, it will not dissolve even at room temperature, especially in winter even during drip. Due to the presence of subtle crystals in the infusion, it is difficult to identify whether there are mold and foreign body, affecting the rescue of critically ill patients. To solve the problem of mannitol crystallization, we based on mannitol and