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目的:对新生儿乙肝疫苗接种效果监测,对阴性儿童再次免疫效果研究提供科学依据。方法:随机抽取2014年3月~2016年3月,在长顺县妇幼保健院预防接种门诊接种疫苗的健康儿童120名(第一针乙肝疫苗接种均为出生医院)作为本次监测对象;按照“0、1、6”免疫程序接种3剂酿酒酵母重组乙型肝炎疫苗(以下简称乙肝疫苗),其对于阴性、弱阳性儿童分别使用乙肝疫苗再次接种3剂;采集监测对象静脉血液,分离出血清,采用化学发光为例子免疫的方法对HBs滴度进行检测,评价疫苗的实际接种效果。结果:长顺县120名儿童乙肝疫苗接种效果监测中,抗-HBs阳性102例,阳性率为85%;乡镇卫生院出生儿童乙肝表面抗体阳性率为72.97%,县级医出生儿童乙肝表面抗体阳性率为90.36%,两者差异有统计学意义(=6.07,P<0.05);儿童出生时父母HBeAg阳性,其儿童接种乙肝疫苗后阳性率为45.45%;18名儿童乙肝表面抗体为阴性者,6名儿童再次接种乙肝疫苗1剂次,12名儿童再次接种乙肝疫苗3剂次,30天后再次检测乙肝表面抗体,其阳性率为88.89%,两者差异有统计学意义(=6.13,p<0.05)。结论:长顺县按国家免疫程序继续接种酿酒酵母重组乙型肝炎疫苗,父母HBsAg呈阴性与出生于县级以上医院新生儿的阳性率相对较高,再次接种乙肝疫苗可以提高儿童乙肝表面抗体。
OBJECTIVE: To monitor the effect of neonatal hepatitis B vaccination and provide scientific basis for the study of the re-immunization effect of negative children. Methods: From March 2014 to March 2016, 120 healthy children vaccinated at outpatient immunization clinics of Changshun MCH (first-dose hepatitis B vaccination were all born hospitals) were randomly selected as the monitoring subjects. According to “0,1,6 ” immunization program three doses of Saccharomyces cerevisiae recombinant hepatitis B vaccine (hereinafter referred to as hepatitis B vaccine), for negative, weakly positive children were vaccinated with hepatitis B vaccine again three; collection of monitoring object venous blood, The serum was separated and the chemiluminescence was used as an example to test the HBs titer to evaluate the actual inoculation effect of the vaccine. Results: Among the 120 children in Changshun County, 102 were positive for anti-HBs, the positive rate was 85%. The positive rate of HBsAg in children born in township hospitals was 72.97%. The HBsAg The positive rate was 90.36%, the difference was statistically significant (= 6.07, P <0.05); the children were born HBeAg positive parents, the children were vaccinated with hepatitis B vaccine positive rate was 45.45%; 18 children with hepatitis B surface antibody was negative , 6 children were re-vaccinated with hepatitis B vaccine for 1 dose, 12 children were re-vaccinated with 3 doses of hepatitis B vaccine, and the detection rate of HBsAg was 88.89% again after 30 days. The difference was statistically significant (= 6.13, p <0.05). Conclusion: Changshun County continues to receive recombinant hepatitis B vaccine of Saccharomyces cerevisiae according to the national immunization program. The positive rate of HBsAg negative parents and newborns born in hospitals above county level is relatively high. Re-vaccination of hepatitis B vaccine can improve hepatitis B surface antibody in children.