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虽然早在50多年前人们就已认识急性巨核细胞白血病(AMKL),但一些分化差的 AMKL,依靠细胞形态学及普通细胞化学不能识别,经常被划为未分化型白血病。近来,应用识别巨核-血小板系列抗原的单克隆抗体,已可识别分化差的 AMKL。本文作者应用两种单克隆抗体研究了墨西哥协作组1年来诊断的21例细胞形态符合 FAB 分类法的M_1,L_2或 Mo 的病人。经检查,6例病人为 AMKL,
Although acute megakaryocyte leukemia (AMKL) has been recognized more than 50 years ago, some poorly differentiated AMKL, often referred to as undifferentiated leukemia, are not recognized by cell morphology and normal cytochemistry. Recently, the use of monoclonal antibodies that recognize megakaryocyte-platelet antigens has allowed the identification of poorly differentiated AMKL. The authors used two monoclonal antibodies to study 21 patients diagnosed with M_1, L_2, or Mo with FAB classification in the Mexico Collaboration 1-year-old. After examination, 6 patients were AMKL,