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体外试验表明人参总甙(SPG),西洋参总甙(SPQ)和三七总甙(SPNG)均能抑制胶原诱导的大鼠血小板聚集,其IC_(50)分别为0.583,1.012及0.815mg·ml~(-1),对胶原诱导引起的血小板5-HT释放,在0.5mg·ml~(-1)时,SPG,SPQ及SPNG的抑制率分别为20％,4％及16％,对血小板内cAMP含量,在35mg·kg~(-1)iv后,SPG,SPQ及SPNG均能使其显著增加.体内试验,对大鼠的实验性血栓,SPNG在80mg·kg~1 ig 1.5～2 h后有显著的抑制作用,但同样剂量的SPG无效Rg_1 20mg·kg~1 ig能显著抑制血栓形成,iv能显著抑制凝血酶所致DIC的血小板数目减少,FDP的增加,但对纤维蛋白原,凝血酶原时间的改变则无明显的拮抗作用。
In vitro, Ginsenosides (SPG), Panax quinquefolium (SPQ) and Panax notoginseng glycosides (SPNG) all inhibited collagen-induced platelet aggregation in rats with IC50 of 0.583, 1.012 and 0.815 mg · ml -1 ~ (-1), respectively. The release of 5-HT on platelets induced by collagen was 20%, 4% and 16% for SPG, SPQ and SPNG at 0.5mg · ml ~ (-1) The content of cAMP increased significantly after SPG, SPQ and SPNG at 35 mg · kg ~ (-1) iv. In vivo, the experimental thrombosis in rats, SPNG at 80mg · kg ~ 1 ig 1.5 ~ 2 h, but the same dose of SPG invalid Rg_1 20mg · kg ~ 1 ig can significantly inhibit thrombosis, iv can significantly inhibit thrombin DIC platelet number decreased, FDP increased, but fibrinogen , Prothrombin time change no obvious antagonism.