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目的:探讨抑癌基因p16及肿瘤抑制基因nm23-H1在膀胱中的表达及临床意义。方法:应用免疫组织化学s-p法检测18例正常膀胱组织中及38例膀胱移行细胞癌组织中p16及nm23-H1的表达。结果:p16在正常组织、膀胱癌中阳性表达率分别为88.8％(16/18),47.4％(18/38),二者间有显著差异性(P<0.01)。nm23-H1在正常膀胱组织、膀胱癌中阳性表达率分别为83.3％(15/18),44.7％(17/38),二者间有显著差异(P<0.01)。提示p16,nm23-H1阳性表达率与膀胱移行细胞癌的临床分期、临床分级、肿瘤大小及是否转移有密切关系。结论:p16、nm23-H1在膀胱癌中的阳性表达对抑制肿瘤生长、浸润和转移起重要作用,可作为膀胱癌患者预测转移和预后及判断膀胱移行细胞癌生物学行为的良好指标。
Objective: To investigate the expression of tumor suppressor gene p16 and tumor suppressor gene nm23-H1 in the bladder and its clinical significance. Methods: Immunohistochemistry s-p method was used to detect the expression of p16 and nm23-H1 in 18 cases of normal bladder tissue and 38 cases of bladder transitional cell carcinoma. Results: The positive expression rates of p16 in normal tissues and bladder cancer were 88.8% (16/18) and 47.4% (18/38), respectively. There was significant difference between them (P <0.01). The positive rates of nm23-H1 in normal bladder tissues and bladder cancer were 83.3% (15/18) and 44.7% (17/38), respectively, with significant difference (P <0.01). These results suggest that the positive rate of p16 and nm23-H1 is closely related to the clinical stage, clinical grade, tumor size and metastasis of bladder transitional cell carcinoma. Conclusion: The positive expression of p16 and nm23-H1 in bladder cancer plays an important role in the inhibition of tumor growth, invasion and metastasis. It can be used as a good indicator for predicting the metastasis and prognosis of bladder cancer and determining the biological behavior of bladder transitional cell carcinoma.