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本文介绍11例蕈样肉芽肿(MF)的患者单独应用重组α-干扰素(rIFN-α2α~2)或联合应用维甲酸(依曲替酯)治疗,可使病情缓解。在11例受试者中女3例,男8例,年龄43～70岁,病程2～20年,病情Ⅱ期5例,Ⅳa 期4例,Ⅳb 期3例(其中例10受试2次),研究前有7例接受过PUVA、氮芥,化疗、X 线、皮质类固醇等治疗。治疗方案:rIFN-α2a~23×10~6U 皮下给药3天,然后每4天增加剂量到9×10~6,18×10~6、36×10~6U/d,3个月后改为每周给药3次,共12个月。同时对例1、4、6、9、10和11每天给依曲替酯0.7mg/kg,其余患者不给,以便评价单用rIFN-α2a~2的作用。临床检查和实验室检室每2周进行1次,共2个月,然后每月检查1次。每月检测rlFN-α2a~2抗
This article describes the 11 cases of patients with mycosis fungoides (MF) of recombinant interferon alpha alone (rIFN-α2α ~ 2) or a combination of retinoic acid (etrotriter) treatment, can make the disease remission. Among the 11 subjects, 3 were female and 8 were male, ranging in age from 43 to 70 years with a course of 2 to 20 years. Five were in stage II, four in stage IVa, and three in stage IVb (of which 10 were tested twice ), Before the study 7 cases received PUVA, nitrogen mustard, chemotherapy, X-ray, corticosteroids and other treatment. Treatment regimen: rIFN-α2a ~ 23 × 10 ~ 6U subcutaneous administration for 3 days, and then every 4 days to increase the dose to 9 × 10 ~ 6,18 × 10 ~ 6,36 × 10 ~ 6U / d, 3 months after the change 3 times a week for a total of 12 months. At the same time, for example, 1,4,6,9,10 and 11 according to etrotine ester 0.7mg / kg, the remaining patients do not give in order to evaluate the role of rIFN-α2a ~ 2 alone. Clinical examination and laboratory seizure every 2 weeks, a total of 2 months, and then check once a month. RlFN-α2a ~ 2 anti-monthly test