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本实验研究基于磁共振T-Map的HIFU损伤组织的热剂量与实际凝固性坏死的关系。运用磁共振导航高强度聚焦超声治疗系统,使用1 MHz、焦距为150 mm、直径150 mm的聚焦超声换能器,定点辐照深度为20 mm的新鲜离体牛肝脏,辐照过程中用磁共振的测温序列采集各体素随时间变化的温度值并计算各体素的Eq43值,比较计算结果与发生凝固性坏死的Eq43参考阈值,判断该体素是否发生坏死。最后比较通过等效热剂量积分法得到的凝固性坏死面积和组织实际发生坏死的情况。结果表明基于磁共振T-Map的等效热剂量积分法得到的凝固性坏死的面积值能很好的反应实际发生凝固性坏死的情况,为HIFU治疗提供了一种新的判断凝固性坏死发生的方法,这种方法可以实时地反馈控制超声辐照剂量,提高了治疗的安全性。
This study was based on magnetic resonance T-Map HIFU injury tissue thermal dose and the actual coagulation necrosis. Using magnetic resonance imaging (HIFU) focused ultrasound system, a freshly prepared in vitro irradiated bovine liver was spot-irradiated at a depth of 20 mm using a focused ultrasound transducer at 1 MHz with a focal length of 150 mm and a diameter of 150 mm. Resonance temperature sequence collected each voxel with temperature over time and calculate the value of each voxel Eq43 comparison of the calculated results and coagulation necrosis of the Eq43 reference threshold to determine whether the necrosis of the voxel. Finally, the area of coagulation necrosis and the actual necrosis of the tissue obtained by the equivalent thermal dose integration method were compared. The results showed that the area value of coagulation necrosis based on the equivalent thermal dose integration method of magnetic resonance T-Map can well reflect the actual occurrence of coagulation necrosis, which provides a new judgment for the occurrence of coagulation necrosis in HIFU treatment Method, this method can feedback control ultrasound dose in real time, improve the safety of treatment.