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目的:观察川芎嗪注射液联合硫酸镁治疗早发型重度子痫前期的作用及对妊娠结局的影响,寻求治疗早发型重度子痫前期的新方法。方法:选取我院74例早发型重度子痫前期(孕28～32周)患者,按入院顺序分为治疗组和对照组各37例,对照组37例采用传统硫酸镁治疗方案,治疗组37例在硫酸镁治疗基础上加用川芎嗪注射液治疗,观察2组患者治疗前后血流变的各项指标、D一二聚体及妊娠结局的变化。结果:治疗组患者血流变指标改善明显优于对照组,血浆D-二聚体水平明显下降,孕周明显延长,胎儿窘迫发生率明显减少,新生儿死亡率显著减少(P<0.05);而对照组治疗前后比较差异无统计学意义(P>0.05)。结论:川芎嗪注射液联合硫酸镁治疗早发型重度子痫前期,可改善患者血液的高凝状态,孕周延长,降低新生儿死亡的发生率。
Objective: To observe the effect of ligustrazine injection combined with magnesium sulfate on early-onset severe preeclampsia and its effect on pregnancy outcome, and to find a new method to treat early-onset severe preeclampsia. Methods: Totally 74 patients with early-onset severe preeclampsia (28-32 weeks of gestation) in our hospital were divided into treatment group (37 cases) and control group (37 cases), and control group (37 cases) Cases of magnesium sulfate treatment based on the addition of ligustrazine injection treatment, observed two groups of patients before and after treatment of blood rheology indicators, D-dimer and pregnancy outcome changes. Results: The indexes of hemorrheology in the treatment group were significantly better than those in the control group. The plasma D - dimer levels were significantly decreased, the gestational age was significantly prolonged, the incidence of fetal distress was significantly reduced, and neonatal mortality was significantly reduced (P <0.05). The control group before and after treatment was no significant difference (P> 0.05). Conclusion: Ligustrazine injection combined with magnesium sulfate in early-onset severe preeclampsia can improve the blood hypercoagulability, extend the gestational age and reduce the incidence of neonatal death.