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目的探讨不同TOAST病因学分型急性脑梗死(ACI)患者血清超敏C-反应蛋白(hs-CRP)水平及相关因素的关系。方法ACI住院患者116例,在发病72h之内测定血清hs-CRP的水平及其他生化指标,应用TOAST病因分型分类后,各亚型与30例健康对照者进行对比。结果除其他明确病因型(SOE)因病例少未作分析,其他ACI各亚型血清hs-CRP水平明显高于对照组(P<0.05),其中大动脉粥样硬化(LAA)型血清hs-CRP水平增高最显著,明显高于其他亚型;心源性栓塞(CE)型血清hs-CRP水平明显高于小动脉闭塞(SAO)型和不明原因(SUE)型。hs-CRP分别与收缩压(SBP,r=0.322,P=0.022)、总胆固醇(TC,r=0.322,P=0.021)、低密度脂蛋白-胆固醇(LDL-C,r=0.358,P=0.011)、糖化血红蛋白(HbA1c,r=0.271,P=0.032)、纤维蛋白原(Fbg,r=0.289,P=0.029)、同型半胱氨酸(Hcy,r=0.301,P=0.023)呈正相关。结论血清hs-CRP水平在不同亚型的ACI明显不同,hs-CRP水平与动脉粥样硬化的发生有一定相关性。
Objective To investigate the relationship between serum hs-CRP levels and related factors in patients with TOAST etiology-associated acute cerebral infarction (ACI). Methods A total of 116 hospitalized patients with ACI were enrolled in this study. Serum hs-CRP levels and other biochemical parameters were measured within 72 hours after onset. The relatives of the subtypes and 30 healthy controls were compared using TOAST etiological classification. Results The levels of serum hs-CRP in other subtypes of ACI were significantly higher than those in the control group (P <0.05), except for the other SOEs. There was no significant difference in serum hs-CRP levels among the patients with large atherosclerosis (LAA) The level of serum hs-CRP was significantly higher than that of other subtypes. The level of hs-CRP in cardioembolic (CE) serum was significantly higher than that of SAO and SUE. hs-CRP were significantly correlated with systolic blood pressure (SBP, r = 0.322, P = 0.022), total cholesterol (TC, r = 0.322, P = 0.021), and LDL-C 0.011), HbA1c (r = 0.271, P = 0.032), fibrinogen (Fbg, r = 0.289, P = 0.029) and homocysteine (Hcy, r = 0.301, P = 0.023) . Conclusions The serum hs-CRP levels in different subtypes of ACI were significantly different, hs-CRP levels and atherosclerosis have a certain correlation.