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目的通过观察心力衰竭患者中血浆同型半胱氨酸(Hcy)的浓度,探讨其临床意义与价值。方法选取54例心力衰竭患者为实验组,另选50例健康人为对照组,统计高同型半胱氨酸血症的发生率并比较其差异;根据心功能NY HA分级,将实验组研究对象进一步分组,观察血浆Hcy的浓度,分别与对照组及组间进行比较。结果实验组高同型半胱氨酸血症的发生率高于对照组,差异有统计学意义(P<0.05)。实验组各亚组间,随着心力衰竭分级的增加,血浆Hcy的浓度也逐渐升高,且各亚组间差异具有统计学意义(P<0.05),与对照组比较差异有统计学意义(P<0.05)。讨论心力衰竭患者中发生高同型半胱氨酸血症的情况普遍存在,且血浆Hcy的浓度随心力衰竭加重而增加,Hcy可作为心力衰竭的独立危险因素之一,也可为心力衰竭严重程度提供新的临床指标和依据。
Objective To investigate the clinical significance and value of plasma homocysteine (Hcy) concentration in patients with heart failure. Methods Fifty-four patients with heart failure were selected as the experimental group and 50 healthy individuals as the control group. The incidence of hyperhomocysteinemia was calculated and compared. According to NYHA classification of heart function, the subjects in the experimental group were further studied Grouping, plasma Hcy concentrations were observed, respectively, compared with the control group and the group. Results The incidence of hyperhomocysteinemia in the experimental group was significantly higher than that in the control group (P <0.05). Plasma concentration of Hcy also gradually increased with the increase of heart failure grading in each subgroup of experimental group, and there was a significant difference between each subgroup (P <0.05), and there was significant difference compared with control group (P < P <0.05). To discuss the prevalence of hyperhomocysteinemia in patients with congestive heart failure, and the plasma concentration of Hcy increased with worsening heart failure, Hcy may serve as an independent risk factor for heart failure, but also for the severity of heart failure Provide new clinical indicators and basis.