论文部分内容阅读
目的:探讨2型糖尿病(type 2 diabetes mellitus,T2DM)合并代谢综合征(metabolic syndrome,MS)患者颈围与胰岛素抵抗、血清超敏C反应蛋白(hs-CRP)的关系。方法:选择研究对象165例,其中对照组55例,单纯2型糖尿病组(T2DM组)55例,T2DM合并MS组(MS组)55例。所有研究对象测量颈围,行口服葡萄糖耐量试验(OGTT)及胰岛素释放试验,并检测血脂、血清hs-CRP等相关生化指标。结果:MS组的颈围为(38.47±3.68)cm,大于正常对照组(35.17±3.09)cm及T2DM组(36.86±2.92)cm(P<0.05或P<0.01);MS组血清hs-CRP水平为[2.77(1.19~5.55)]mg/L,显著高于正常对照组[0.40(0.18~0.98)]mg/L及T2DM组[1.74(0.81~5.33)]mg/L(P<0.01)。随着颈围水平的升高,体质量指数(BMI)、腰围、腰臀比、空腹胰岛素(FINS)、餐后2h胰岛素(PSI)、三酰甘油、胰岛素抵抗指数(HOMA-IR)及hs-CRP水平显著升高,高密度脂蛋白胆固醇(HDL-C)水平显著降低。简单相关分析显示,颈围与BMI、腰围、腰臀比、舒张压、空腹血糖、餐后2h血糖(2hPG)、FINS、PSI、三酰甘油、低密度脂蛋白胆固醇(LDL-C)、HOMA-IR及hs-CRP呈正相关(P<0.05或P<0.01),与HDL-C呈显著负相关(P<0.01);Logistic回归分析显示,颈围、腰围、三酰甘油是T2DM合并MS的危险因素,HDL-C是其保护因素(P<0.01)。结论:新诊断T2DM合并MS患者颈围明显增加,其与胰岛素抵抗、血清hs-CRP水平密切相关,颈围是T2DM合并MS的危险因素。
Objective: To investigate the relationship between cervical circumference and insulin resistance and serum hs-CRP in patients with type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS). Methods: A total of 165 subjects were selected, including 55 in control group, 55 in T2DM group and 55 in T2DM combined with MS group. All subjects were measured neck circumference, oral glucose tolerance test (OGTT) and insulin release test, and serum lipid, serum hs-CRP and other biochemical indicators. Results: The neck circumference of MS group was (38.47 ± 3.68) cm, which was significantly higher than that of normal control group (35.17 ± 3.09 cm) and T2DM group (36.86 ± 2.92 cm, P <0.05 or P <0.01) The level of [2.77 (1.19-5.55)] mg / L was significantly higher than that of the control group [0.40 (0.18-0.98) mg / L and T2DM group 1.74 (0.81-5.33) mg / L, . Body mass index (BMI), waist circumference, waist-hip ratio, fasting insulin (FINS), postprandial insulin 2h (PSI), triglyceride, insulin resistance index (HOMA-IR) and hs -CRP levels were significantly increased, high-density lipoprotein cholesterol (HDL-C) levels were significantly lower. Simple correlation analysis showed that there were significant differences between neck circumference and BMI, waist circumference, waist-to-hip ratio, diastolic blood pressure, fasting blood glucose, postprandial 2h blood glucose (2hPG), FINS, PSI, triglyceride, low density lipoprotein cholesterol -IR and hs-CRP (P <0.05 or P <0.01), but negatively correlated with HDL-C (P <0.01). Logistic regression analysis showed that neck circumference, Risk factors, HDL-C is its protective factor (P <0.01). CONCLUSION: The neck circumference of newly diagnosed T2DM patients with MS is significantly increased, which is closely related to insulin resistance and serum hs-CRP levels. The neck circumference is a risk factor for T2DM with MS.