论文部分内容阅读
抗癌药顺铂,是分子中含有铂的化合物,是铂络合物抗癌药的一种.对膀胱癌、卵巢癌、睾丸癌以及部分胃癌有效,在美国大量使用,但表现出很强的肾毒性、骨髓毒性、神经毒性、消化道毒性,所以它的使用最受到限制. 北里大学药学系公共卫生教研室井村伸教授、水沼章副教授、北里研究所医院药剂科没谷清氏等用19种中药作了抑制顺铂毒性的小白鼠动物试验.结果认为,十全大补汤、三黄泻心汤的抑制作用较好. 实验的方法是第一组小白鼠6只,只给致死量的顺铂,小白鼠从第三天开始死亡,到第18天全部死光。第二组小白鼠6只,给同样致死量的顺铂,3只在给该药的前5天到给该药后的第4天,连
The anticancer drug cisplatin, which is a compound containing platinum in the molecule, is a kind of platinum complex anticancer drug. It is effective against bladder cancer, ovarian cancer, testicular cancer, and part of gastric cancer. It is used in large quantities in the United States, but it has shown strong Because of its nephrotoxicity, bone marrow toxicity, neurotoxicity, and gastrointestinal toxicity, its use is most limited. There are 19 kinds of medicines such as Prof. Masahiro Ishimura, Associate Professor Suganuma, Department of Pharmacy, Kitasato University Faculty of Pharmacy, Kitahara, etc. Chinese medicine was used to inhibit the toxicity of cisplatin in mice. The results showed that Shiquan Dabu Decoction and Sanhuang Xiexin Decoction had better inhibitory effects. The experimental method was the first group of mice and only gave lethal doses. Cisplatin, mice died from the third day and all died on the 18th day. Six rats in the second group were given the same lethal dose of cisplatin, and three were on the fourth day after giving the drug five days before giving the drug.