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目的：进一步了解特发性血小板减少性紫癜（ＩＴＰ）的免疫发病机理。方法：采用固相血小板免疫血清学试验，检验２６例急性ＩＴＰ的外周血抗血小板抗体；用ＡＰＡＡＰ法检验３３例ＩＴＰ的外周血Ｔ细胞亚群，同时测定１９例健康儿童的外周血Ｔ细胞亚群。结果：急性ＩＴＰ患儿的抗血小板抗体总阳性率为４６．２％；ＣＤ３、ＣＤ４及ＣＤ４／ＣＤ８值明显下降（Ｐ＜０．０１），ＣＤ８明显升高（Ｐ＜０．０１），与对照组相比，差异有显著性。结论：急性ＩＴＰ的发病机理与免疫紊乱密切相关。
Objective: To further understand the immune pathogenesis of idiopathic thrombocytopenic purpura (ITP). Methods: Peripheral blood anti-platelet antibodies of 26 patients with acute ITP were tested by solid phase platelet immune serological test. Peripheral blood T lymphocyte subsets of 33 ITP patients were detected by APAAP method. T lymphocyte subsets of 19 healthy children group. Results: The total positive rate of antiplatelet antibody in children with acute ITP was 46.2%, the levels of CD3, CD4 and CD4 / CD8 were significantly decreased (P <0.01) and CD8 was significantly increased (P <0.01) Compared with the control group, the difference was significant. Conclusion: The pathogenesis of acute ITP is closely related to immune disorders.