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应用氢清除法连续测定大鼠一侧纹状体脑血流量（ｒＣＢＦ），并观察丁基苯酞（ＮＢＰ）对其影响．结果表明，ＮＢＰ４０或８０ｍｇ·ｋｇ－１ｉｇ均能显著增加大脑中动脉阻断后纹状体的ｒＣＢＦ（与溶剂对照组相比Ｐ＜０．０１），作用持续３ｈ．此外，５－２０ｍｇ·ｋｇ－１ｉｇ时，也可增加正常大鼠纹状体脑血流，各剂量组ＮＢＰ对平均动脉压均无明显影响；尼莫地平（Ｎｉｍ）０．５ｍｇ·ｋｇ－１ｉｐ也能明显增加纹状体脑血流，同时轻度降低动脉平均压，其增加脑血流作用与ＮＢＰ５ｍｇ·ｋｇ－１的作用相当．提示ＮＢＰ不仅能增加正常大鼠纹状体的脑血流，还能增加大脑中动脉阻断后纹状体的血流量，其抗脑缺血作用可能与该作用有关．
The rCBF of rat striatum was measured continuously by hydrogen scavenging method and the influence of butylphthalide (NBP) on it was observed. The results showed that NBP40 or 80mg · kg-1ig significantly increased the rCBF of the striatum after middle cerebral artery occlusion (P <0.01 compared with the solvent control group) for 3h. In addition, 5-20mg · kg-1ig, can also increase the normal rat cerebral blood flow of striatum, NBP of each dose group had no significant effect on mean arterial pressure; nimodipine (Nim) 0.5mg · kg-1ip Also significantly increased striatum cerebral blood flow, while mildly decreased mean arterial pressure, its increased cerebral blood flow and NBP5mg · kg-1 role. These results suggest that NBP can not only increase cerebral blood flow in normal rat striatum, but also increase the blood flow of striatum after middle cerebral artery occlusion. Its anti-ischemic effect may be related to this effect.