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采用免疫组化ABC法对喉及喉咽癌60例,良性喉病变14例进行雄激索受体(AR)检测。结果表明:喉及喉咽癌AR总的阳性率为71.7%(43/60)。良性病变均为阴性。AR阳性率与性别、癌肿分化程度、癌肿部位、T分类无关。但与年龄有关,即AR阳性率随患者年龄升高而降低。认为喉癌是雄激素的依赖肿瘤。AR阳性率与是否有颈淋巴转移有密切关系。即结果显示N+组88.5%明显高于No组57.1%(P<0.05)。故认为AR的检测有利于判断喉癌患者的预后和制定治疗方案的参考。
Sixty cases of laryngeal and hypopharyngeal carcinoma and 14 cases of benign laryngeal lesions were examined by immunohistochemical ABC method. The results showed that the total positive rate of AR in laryngeal and hypopharyngeal carcinoma was 71.7% (43/60). All benign lesions were negative. The positive rate of AR was not related to sex, degree of differentiation of cancer, location of tumor and T classification. But with age, that is, the positive rate of AR decreased with the age of patients. Laryngeal cancer is thought to be androgen-dependent tumors. AR positive rate and whether there is a close relationship between cervical lymph node metastasis. The results showed that 88.5% of the N + group was significantly higher than 57.1% of the No group (P <0.05). Therefore, the detection of AR is conducive to determine the prognosis of laryngeal cancer patients and to develop a reference for treatment options.