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【目的】探讨FoxO1基因rs17446593单核苷酸多态性与2型糖尿病（T2DM ）的关系。【方法】395例T2DM患者和366例对照组，用分子量阵列技术（MassARRAY）方法检测FoxO1基因 rs17446593单核苷酸多态性，并用SPSS13．0统计软件进行分析。【结果】FOXO1基因 rs17446593在 T2DM 组GG、GA 型及AA型分别为1．77％、27．09％及71．14％，在对照组GG、GA型及AA型分别为1．64％、20．22％及78．14％（两组间χ2＝5．0460，P ＝0．080）。G等位基因在两组分别为15．32％，及11．75％（两组间χ2＝4．116，P ＝0．042）。【结论】FoxO1基因 rs17446593 G等位基因可能是T2DM的易感基因。“,”[Objective]To explore the correlation between FOXO1 gene rs17446593 polymorphism and type 2 diabetes mellitus(T2DM ) .[Methods] A total of 395 patients with T2DM and 366 control subjects were chosen .MassARRAY method was used to determine FOXO1 gene rs17446593 polymorphism .SPSS13 .0 sta-tistical software was used for the analysis .[Results] The frequencies of genotype GG ,GA and AA of FOXO1 gene rs17446593 in T2DM group were 1 .72% ,27 .09% and 71 .14% ,respectively ,and those in control group were 1 .64% ,20 .22% and 78 .14% ,respectively (χ2 = 5 .0460 ,P =0 .080 between two groups) .The fre-quencies of G allele in two groups were 15 .32% and 11 .75% ,respectively (χ2 =4 .116 ,P =0 .042 between two groups) .[Conclusion]Allele G of FOXO1 gene rs17446593 may be the predisposing gene of T2DM .