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Bru6ea antidysenterica Mill.是苦木科鸦胆子属的一种树,在埃塞俄比亚用于治癌。作者从其树皮(叶、树木亦有效)乙醇提取物分离得到鸦胆丁(Bruceatin,下简称Ⅰ)和鸦胆他宁(Bruceatarin,下简称Ⅱ)。Ⅰ对体外人体鼻咽癌KB细胞及小鼠白血病P-388均有很强的抑制作用;Ⅱ对P-388仅有中等强度的抑制作用。以KB细胞和P-388进行筛选,显示上述醇提取物的活性依次集中在氯仿-水分配的氯仿层(1),10%含水甲醇-石油醚分配的甲醇层(2),20%含水甲醇-四氯化碳分配的甲醇层(3)及氯仿-40%含水甲醇分配的氯仿
Bru6ea antidysenterica Mill. Is a tree of the genus Petaciscus used to treat cancer in Ethiopia. The authors isolated Bruceatin (Bruxelin) and Bruceatarin (Bruxelles II) from their bark (leaf and tree also effective) ethanol extract. Ⅰ has a strong inhibitory effect on human nasopharyngeal carcinoma KB cells and mouse leukemia P-388 in vitro; Ⅱ has only a moderate inhibitory effect on P-388. Screening with KB cells and P-388 showed that the activity of the above alcohol extracts was concentrated sequentially in a chloroform-water-partitioned chloroform layer (1), a 10% aqueous methanol-petroleum ether-partitioned methanol layer (2), a 20% aqueous methanol - Carbon tetrachloride partitioned methanol layer (3) and chloroform - 40% aqueous methanol distribution of chloroform