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目的探讨三联药物治疗与牙周基础治疗对幽门螺杆菌(Hp)清除率的影响。方法抽选93例经胃镜诊断为消化性溃疡、活检尿素酶试验阳性且合并有慢性牙周炎的患者,采用随机分层法分对照组(例数=45例,予以三联药物治疗)和观察组(例数=48例,在三联药物治疗的同时还予以了牙周基础治疗),治疗结束后分别于3、6个月采用聚合酶链式反应法(PCR)检测患者口腔及胃部Hp清除率,观察观察组牙周临床指数变化。结果观察组患者牙周治疗后的菌斑指数(PLI)、探诊深度(PD)、出血指数(BI)与治疗前比较明显好转(P<0.05)。观察组患者3、6个月的口腔Hp清除率均明显高于对照组(P<0.05);胃部Hp清除率至6个月时亦显著高于对照组(P<0.05)。结论对消化性溃疡合并有慢性牙周炎的患者予以三联药物治疗的同时予以口腔专科牙周基础治疗,能显著提高胃内Hp远期根除率。
Objective To investigate the effects of triple drug therapy and periodontal treatment on the clearance rate of Helicobacter pylori (Hp). Methods Ninety-three patients diagnosed as peptic ulcer by gastroscope, biopsied urease test positive with chronic periodontitis were randomly divided into control group (n = 45, triple therapy) and observation Group (n = 48). Periodontal basic treatment was given along with triple drug therapy. The oral cavity and stomach Hp were detected by polymerase chain reaction (PCR) at 3 and 6 months after the treatment, respectively Clearance rate, observe the observation group periodontal clinical index changes. Results The plaque index (PLI), probing depth (PD) and hemorrhage index (BI) in the observation group were significantly improved after treatment (P <0.05). The oral Hp clearance rate in observation group was significantly higher than that in control group at 3 and 6 months (P <0.05). The clearance rate of Hp in stomach was also significantly higher than that of control group at 6 months (P <0.05). Conclusion Patients with peptic ulcer complicated with chronic periodontitis should be treated with triple drug therapy and be given oral periodontal basic treatment, which can significantly improve the long-term eradication rate of Hp in the stomach.