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氟化物的遗传毒性日益引起人们的重视 ,但目前人们对其研究多局限于细胞水平和染色体水平。端粒目前被认为是细胞有丝分裂的“生物钟” ,而端粒酶是影响端粒长度的主要因素 ,细胞恶变时其活性增强。我们利用较先进的定性及定量方法从分子水平探讨氟化钠 (ＮａＦ)对端粒酶改变的
The genetic toxicity of fluoride has drawn more and more attention, but at present it is mostly confined to cellular and chromosomal levels. Telomeres are currently thought to be the “circadian clock” of mitosis, and telomerase is a major factor affecting telomere length, with enhanced activity in malignant cells. We use more advanced qualitative and quantitative methods to explore the molecular level of sodium fluoride (NaF) on telomerase changes