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为从细胞凋亡角度探讨米非司酮终止早期妊娠的机理，采用免疫组织化学方法并结合计算机图像分析检测了细胞凋亡基因白细胞介素１β转换酶（ＩＣＥ）和Ｆａｓ在人早期妊娠绒毛组织中的表达及米非司酮对其的影响。结果：上述两种基因的蛋白表达产物在早期妊娠绒毛各组成细胞中均有表达，且以合体滋养细胞中的表达最为明显；ＩＣＥ表现为细胞浆阳性着色，Ｆａｓ以细胞浆阳性为主，部分为细胞膜或全细胞阳性，核为主。应用米非司酮２天后，各绒毛组分ＩＣＥ表达增强，但无统计学意义（Ｐ＞００５），Ｆａｓ表达明显增强，以核为主的全细胞阳性比例显著增加（Ｐ＜００１）。由此提示，米非司酮终止早期妊娠可能是通过增强Ｆａｓ表达，促进细胞凋亡来实现的
To investigate the mechanism of mifepristone termination of early pregnancy from the perspective of apoptosis, the expression of interleukin 1 beta converting enzyme (ICE) and Fas in human early pregnancy chorionic villus tissue were detected by immunohistochemistry and computer image analysis. In the expression of mifepristone and its impact. Results: The protein expression products of the above two genes were expressed in the constituent cells of early pregnancy villi, and the expression was most obvious in syncytiotrophoblasts. ICE showed cytoplasm positive staining, Fas mainly positive cytoplasm, For the cell membrane or whole cell positive, nuclear-based. After 2 days of application of mifepristone, the expression of ICE in each villus was increased, but there was no statistical significance (P> 005). The expression of Fas was significantly increased and the percentage of nucleus-dominant whole cells was significantly increased (P <0 01). This suggests that the termination of early pregnancy with mifepristone may be achieved by enhancing Fas expression and promoting apoptosis